2167898-24-8
2167898-24-8 structure
- Name: Ribociclib-d8
- Chemical Name: Ribociclib-d8
- CAS Number: 2167898-24-8
- Molecular Formula: C23H22D8N8O
- Molecular Weight: 442.59
- Catalog: Signaling Pathways Cell Cycle/DNA Damage CDK
- Create Date: 2023-04-20 19:17:08
- Modify Date: 2024-01-17 11:02:22
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Ribociclib-d8 is the deuterium labeled Ribociclib[1]. Ribociclib (LEE01) is a highly specific CDK4/6 inhibitor with IC50 values of 10 nM and 39 nM, respectively, and is over 1,000-fold less potent against the cyclin B/CDK1 complex[2].
| Name | Ribociclib-d8 |
|---|
| Description | Ribociclib-d8 is the deuterium labeled Ribociclib[1]. Ribociclib (LEE01) is a highly specific CDK4/6 inhibitor with IC50 values of 10 nM and 39 nM, respectively, and is over 1,000-fold less potent against the cyclin B/CDK1 complex[2]. |
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| Related Catalog | |
| In Vitro | Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1]. |
| References |
| Molecular Formula | C23H22D8N8O |
|---|---|
| Molecular Weight | 442.59 |