2012598-34-2

2012598-34-2 structure

Name: Carprofen-13C,d3
Chemical Name: Carprofen-13C,d3
CAS Number: 2012598-34-2
Molecular Formula: C₁₄₁₃CH₉D₃ClNO₂
Molecular Weight: 277.73
Catalog: Signaling Pathways Autophagy Autophagy
Create Date: 2023-04-27 15:16:21
Modify Date: 2024-01-17 10:25:43
Carprofen-13C,d3 is the deuterium and 13C labeled Carprofen[1]. Carprofen is a nonsteroid anti-inflammatory agent, acts as a multi-target FAAH/COX inhibitor, with IC50s of 3.9 μM, 22.3 μM and 78.6 μM for COX-2, COX-1 and FAAH, respectively[2][3][4].

Name	Carprofen-13C,d3

Description	Carprofen-13C,d3 is the deuterium and 13C labeled Carprofen[1]. Carprofen is a nonsteroid anti-inflammatory agent, acts as a multi-target FAAH/COX inhibitor, with IC50s of 3.9 μM, 22.3 μM and 78.6 μM for COX-2, COX-1 and FAAH, respectively[2][3][4].
Related Catalog	Signaling Pathways >> Autophagy >> Autophagy Research Areas >> Inflammation/Immunology Signaling Pathways >> Metabolic Enzyme/Protease >> FAAH Signaling Pathways >> Immunology/Inflammation >> COX Signaling Pathways >> Neuronal Signaling >> FAAH
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [2]. Favia AD, et al. Identification and characterization of carprofen as a multitarget fatty acid amide hydrolase/cyclooxygenase inhibitor. J Med Chem. 2012 Oct 25;55(20):8807-26. [3]. Waldherr K, et al. In vitro cytoprotective effects of acetylsalicylic acid, carprofen, meloxicam, or robenacoxib against apoptosis induced by sodium nitroprusside in canine cruciate ligament cells. Am J Vet Res. 2012 Nov73(11):1752-8. [4]. Sessions JK, et al. In vivo effects of carprofen, deracoxib, and etodolac on prostanoid production in blood, gastric mucosa, and synovial fluid in dogs with chronic osteoarthritis. Am J Vet Res. 2005 May66(5):812-7.

Molecular Formula	C₁₄₁₃CH₉D₃ClNO₂
Molecular Weight	277.73

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