309735-96-4
309735-96-4 structure
- Name: USP22-IN-1
- Chemical Name: USP22-IN-1
- CAS Number: 309735-96-4
- Molecular Formula: C22H18N4
- Molecular Weight: 338.41
- Catalog: Research Areas Cancer
- Create Date: 2023-04-04 17:02:23
- Modify Date: 2024-04-06 12:54:03
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USP22-IN-1 (compound S02) is a potent USP22 inhibitor. USP22-IN-1 decreases the expression of FOXP3, USP22 protein and Foxp3 mRNA levels. USP22-IN-1 enhanceds anti -tumor immunity[1].
| Name | USP22-IN-1 |
|---|
| Description | USP22-IN-1 (compound S02) is a potent USP22 inhibitor. USP22-IN-1 decreases the expression of FOXP3, USP22 protein and Foxp3 mRNA levels. USP22-IN-1 enhanceds anti -tumor immunity[1]. |
|---|---|
| Related Catalog | |
| Target |
USP22[1] |
| In Vitro | USP22-IN-1 (compound S02) (0, 5, 10, 15, 20, 25 µg/mL) 以剂量依赖性方式降低 Foxp3 MFI 和细胞活力[1]。 USP22-IN-1 (10 µg/mL; 0-12 h) 降低 iTreg 细胞中 FOXP3、USP22 蛋白和 Foxp3 mRNA 水平的表达[1]。 Cell Viability Assay[1] Cell Line: iTreg cells Concentration: 0, 5, 10, 15, 20, 25 µg/mL Incubation Time: Result: Inhibited cell survival in a dose-dependent manner. Western Blot Analysis[1] Cell Line: iTreg cells Concentration: 10 µg/mL Incubation Time: 0-12 h Result: Decreasesd the expression of FOXP3, USP22 in a time-dependent manner. |
| In Vivo | USP22-IN-1 (20 mg/kg; i.p.; twice a day for 5 days) 增强小鼠的抗肿瘤免疫力[1]。 Animal Model: 6-8 weeks, C57BL/6 male mice (LLC1 cells)[1] Dosage: 20 mg/kg Administration: I.p.; twice a day for 5 days Result: Enhanced anti -tumor immunity in LLC1 -challenged mice, decreased tumor cell counts, viability, and growth. |
| References |
| Molecular Formula | C22H18N4 |
|---|---|
| Molecular Weight | 338.41 |