2622070-93-1

2622070-93-1 structure

Name: (Rac)-Etavopivat
Chemical Name: (Rac)-Etavopivat
CAS Number: 2622070-93-1
Molecular Formula: C₂₂H₂₃N₃O₆S
Molecular Weight: 457.50
Catalog: Research Areas Cardiovascular Disease
Create Date: 2023-04-18 22:23:50
Modify Date: 2024-02-21 09:46:48
(Rac)-Etavopivat ((Rac)-FT-4202) is an isomer of Etavopivat (HY-139573). Etavopivat is an orally active erythrocyte pyruvate kinase-R (PKR) activator that can be used in studies of sickle cell disease and other haemoglobinopathies[1].

Name	(Rac)-Etavopivat

Description	(Rac)-Etavopivat ((Rac)-FT-4202) is an isomer of Etavopivat (HY-139573). Etavopivat is an orally active erythrocyte pyruvate kinase-R (PKR) activator that can be used in studies of sickle cell disease and other haemoglobinopathies[1].
Related Catalog	Research Areas >> Cardiovascular Disease
In Vitro	Etavopivat (20 μM, 4 h)可以改善人红细胞中血红蛋白-氧亲和力并降低了镰状点 (PoS)[1]。
In Vivo	Etavopivat（口服，3-22mg/kg，每天一次，5天）在 8 mg/kg和 22 mg/kg 的剂量下引起食蟹猴 2,3-DPG 和 ATP 的增加[1]。
References	[1]. Patricia Schroeder, et al. Etavopivat, a Pyruvate Kinase Activator in Red Blood Cells, for the Treatment of Sickle Cell Disease. J Pharmacol Exp Ther. 2022 Mar;380(3):210-219.

Molecular Formula	C₂₂H₂₃N₃O₆S
Molecular Weight	457.50