2132411-21-1
2132411-21-1 structure
- Name: QD394
- Chemical Name: QD394
- CAS Number: 2132411-21-1
- Molecular Formula: C19H19N5O2
- Molecular Weight: 349.39
- Catalog: Research Areas Cancer
- Create Date: 2023-05-31 07:40:05
- Modify Date: 2024-02-08 22:07:05
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QD394 is a reactive oxygen species (ROS) inducer that can induce lipid peroxidation, increase intracellular ROS accumulation, inhibit STAT3 phosphorylation, and induce ferroptosis[1].
| Name | QD394 |
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| Description | QD394 is a reactive oxygen species (ROS) inducer that can induce lipid peroxidation, increase intracellular ROS accumulation, inhibit STAT3 phosphorylation, and induce ferroptosis[1]. |
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| Related Catalog | |
| In Vitro | QD394 (0-10 μM, 24 h) is cytotoxic with the IC50 values of 0.64, 0.34 and 0.9 μM for MIA PaCa-2, PANC-1 and BxPC-3 cell lines, respectively. And QD394 can inhibit the phosphorylation of STAT3 in cells and increase the phosphorylation of H2AX[1]. QD394(1-10 μM, 4 h) mediates cell death by increasing cellular ROS levels and decreases GSH/GSSG ratio in MIA PaCa-2 cells; also induces iron-dependent and GPX4-mediated ferroptosis[1]. |
| References |
| Molecular Formula | C19H19N5O2 |
|---|---|
| Molecular Weight | 349.39 |