2244129-23-3
2244129-23-3 structure
- Name: PCSK9-IN-13
- Chemical Name: PCSK9-IN-13
- CAS Number: 2244129-23-3
- Molecular Formula: C30H33N5O2
- Molecular Weight: 495.62
- Catalog: Signaling Pathways Metabolic Enzyme/Protease Ser/Thr Protease
- Create Date: 2023-04-20 14:28:05
- Modify Date: 2025-09-21 06:11:37
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PCSK9-IN-13(compound 3f) is a potent PCSK9 inhibitor, which can antagonize low-density lipoprotein (LDL) receptor binding by binding to PCSK9, with an IC50 of 537 nM[1].
| Name | PCSK9-IN-13 |
|---|
| Description | PCSK9-IN-13(compound 3f) is a potent PCSK9 inhibitor, which can antagonize low-density lipoprotein (LDL) receptor binding by binding to PCSK9, with an IC50 of 537 nM[1]. |
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| Related Catalog | |
| In Vitro | PCSK9-IN-13(compound 3f) (0.1 or 1 μM) 可剂量依赖性的恢复 HepG2 肝细胞对 LDL 的摄取[1]。 |
| In Vivo | PCSK9-IN-13(compound 3f) (3.28 or 16.4 mg/kg/day, s.c., 14 days) 在雄性 C57BL/6 小鼠中，剂量为 3.28 mg/kg 时，小鼠没有表现出总胆固醇降低，然而剂量为 16.4 mg/kg 时显示显著降低了总胆固醇血浆水平约 10%，并表现出优异的生物利用度[1]。 |
| References |
| Molecular Formula | C30H33N5O2 |
|---|---|
| Molecular Weight | 495.62 |