313987-85-8

313987-85-8 structure

Name: Mycro1
Chemical Name: Mycro1
CAS Number: 313987-85-8
Molecular Formula: C₂₀H₁₅F₃N₄O₂S
Molecular Weight: 432.42
Catalog: Research Areas Cancer
Create Date: 2023-04-07 16:22:46
Modify Date: 2024-04-03 19:18:36
Mycro1 is an inhibitor of c-Myc/Max dimer and DNA binding, with an IC50 value of 30 μM for the inhibition of Myc/Max DNA binding activity. Mycro1 can inhibit c-myc-dependent cell proliferation, gene transcription and oncogenic transformation[1].

Name	Mycro1

Description	Mycro1 is an inhibitor of c-Myc/Max dimer and DNA binding, with an IC50 value of 30 μM for the inhibition of Myc/Max DNA binding activity. Mycro1 can inhibit c-myc-dependent cell proliferation, gene transcription and oncogenic transformation[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
In Vitro	Mycro1(10 or 20 μM, 7 days)可以抑制 C-Myc 依赖细胞系 U-2OS、MCF-7、Raji 和 NIH/3T3 的增殖，不会抑制 C-Myc 独立癌细胞株 PC-12 的增殖。Mycro1 在 10 μM 时可以显著抑制 c- myc 诱导的基因转录，在 20 μM 时可以选择性减少 c- myc 转化Rat1a细胞的非锚定生长[1]。
References	[1]. Anke Kiessling, et al. Selective inhibition of c-Myc/Max dimerization and DNA binding by small molecules. Chem Biol. 2006 Jul;13(7):745-51.

Molecular Formula	C₂₀H₁₅F₃N₄O₂S
Molecular Weight	432.42