1621164-74-6
1621164-74-6 structure
- Name: Camlipixant
- Chemical Name: Camlipixant
- CAS Number: 1621164-74-6
- Molecular Formula: C23H24F2N4O4
- Molecular Weight: 458.46
- Catalog: Signaling Pathways Membrane Transporter/Ion Channel P2X Receptor
- Create Date: 2023-04-25 15:25:45
- Modify Date: 2025-09-05 23:34:01
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Camlipixant (BLU-5937) a potent, selective, non-competitive and orally active P2X3 homotrimeric receptor antagonist with an IC50 of 25 nM against hP2X3 homotrimeric. Camlipixant shows potent anti-tussive effect and no taste alteration. Camlipixant can be used for the research of unexplained, refractory chronic cough[1].
| Name | Camlipixant |
|---|
| Description | Camlipixant (BLU-5937) a potent, selective, non-competitive and orally active P2X3 homotrimeric receptor antagonist with an IC50 of 25 nM against hP2X3 homotrimeric. Camlipixant shows potent anti-tussive effect and no taste alteration. Camlipixant can be used for the research of unexplained, refractory chronic cough[1]. |
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| Related Catalog | |
| Target |
IC50: 25 nM (hP2X3), >24000 nM (hP2X2/3), 92 nM (rP2X3), 1820 nM (rP2X2/3), 126 nM (gpP2X3), 3450 nM (gpP2X2/3)[1] |
| In Vitro | Camlipixant (BLU-5937; 500 nM) 阻断 ATP 介导的背根神经节 (DRG) 神经元敏化[1]。 |
| In Vivo | Camlipixant (BLU-5937; 3-30 mg/kg; oral) 减少组胺和 ATP 诱导的豚鼠咳嗽过敏[1]。 Camlipixant (BLU-5937; 10-20 mg/kg; i.p.) 与对照动物相比，不会改变味觉知觉[1]。 Camlipixant (BLU-5937) 表现出优异的类药物特性，包括良好的口服生物利用度，在人体内预测清除率低，无血脑屏障渗透性，安全性高[1]。 Animal Model: Male Dunkin Hartley guinea pigs[1] Dosage: 0.3, 3, 30 mg/kg Administration: PO, approximately 2 h prior to tussive agent exposure Result: Significantly reduced the histamine-induced enhancement in the number of citric acid-induced coughs. Reduced significantly and dose-dependently the ATP-induced enhancement of citric acid-induced coughs. |
| References |
| Molecular Formula | C23H24F2N4O4 |
|---|---|
| Molecular Weight | 458.46 |