1980787-47-0
1980787-47-0 structure
- Name: Belapectin
- Chemical Name: Belapectin
- CAS Number: 1980787-47-0
- Molecular Formula:
- Molecular Weight:
- Catalog: Signaling Pathways Apoptosis Apoptosis
- Create Date: 2023-05-06 19:30:57
- Modify Date: 2024-04-06 18:15:06
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Belapectin (GR-MD-02) is a Galectin-3 (Gal-3) inhibitor. Belapectin drives tumor-induced immunosuppression by inducing T cell Apoptosis. Belapectin promotes tumor regression and improves survival of tumor-bearing mice through a CD8+ T cell-dependent mechanism. Belapectin binds to Gal-3 with affinity Ki of 2.8 μM[1][2].
| Name | Belapectin |
|---|
| Description | Belapectin (GR-MD-02) is a Galectin-3 (Gal-3) inhibitor. Belapectin drives tumor-induced immunosuppression by inducing T cell Apoptosis. Belapectin promotes tumor regression and improves survival of tumor-bearing mice through a CD8+ T cell-dependent mechanism. Belapectin binds to Gal-3 with affinity Ki of 2.8 μM[1][2]. |
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| Related Catalog | |
| Target |
Ki: 2.8 μM (Galectin-3)[2] |
| In Vitro | Belapectin (0.2 mg/mL, 2 mg/mL; 48 h) 抑制 4T1 和 MCA-205 细胞的增殖，诱导凋亡[1]。 Apoptosis Analysis[1] Cell Line: TRAMP-C1, 4T1 and MCA-205 cells Concentration: 0.2 mg/mL, 2 mg/mL Incubation Time: 48 h Result: Decreased the proliferation and resulted a minimal increase in apoptosis of 4T1 and MCA-205 cells. But showed no impact on TRAMP-C1 cell. |
| In Vivo | Belapectin (2.4 mg/mouse; 腹腔注射; 每周 3 次, 共 3 周) 仅与 anti-OX40 mAb 联合处理后，才导致肿瘤生长显著减少、存活率相应增加。联合处理还产生了持久的长期记忆，100% 无瘤小鼠被保护免于随后的肿瘤再攻击[1]。 Animal Model: Wild-type C57BL/6 and BALB/c mice[1] Dosage: 2.4 mg/mouse, accompanied with anti-OX40 mAb (250 µg) Administration: Intraperitoneal injection; 3 times per week for 3 weeks Result: Inhibited tumor growth. Enhanced the efficacy of checkpoint blockade (aPD-L1) immunotherapy. |
| References |
| No Any Chemical & Physical Properties |