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2699768-78-8

2699768-78-8 structure

2699768-78-8 structure

Name: ARN24139
Chemical Name: ARN24139
CAS Number: 2699768-78-8
Molecular Formula: C₂₄H₁₆F₃N₃O₄S
Molecular Weight: 499.46
Catalog: Signaling Pathways Cell Cycle/DNA Damage Topoisomerase
Create Date: 2023-06-19 18:42:21
Modify Date: 2024-04-03 08:54:06
ARN24139(compound 3f) is a topoisomerase II (topoII) inhibitor with the IC50 of 7.3 μM. ARN24139 can inhibit cancer cell proliferation and is well tolerated in vivo[1].

Name	ARN24139

Description	ARN24139(compound 3f) is a topoisomerase II (topoII) inhibitor with the IC50 of 7.3 μM. ARN24139 can inhibit cancer cell proliferation and is well tolerated in vivo[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Topoisomerase
In Vitro	ARN24139(compound 3f) 具有作用于 DU145、HeLa 和 A549 细胞的抗增殖活性，其 IC50 值分别是 4.7、3.8 和 3.1μM[1]。
In Vivo	The pharmacokinetic parameters of ARN24139(compound 3f) in mice Parameter IV (3 mg/kg) PO (10 mg/kg) Cmax(ng/mL) 7366 428 Tmax(min) 5 120 AUCplasma(min*ng/mL) 295528 77385 t1/2(min) 30 190 Vd(L/kg) 3 18 CL(L/min/kg) 0.004 - F(%) 8 8
References	[1]. Jose M Arencibia, et al. Design, Synthesis, Dynamic Docking, Biochemical Characterization, and in Vivo Pharmacokinetics Studies of Novel Topoisomerase II Poisons with Promising Antiproliferative Activity. J Med Chem. 2020 Apr 9;63(7):3508-3521.

Molecular Formula	C₂₄H₁₆F₃N₃O₄S
Molecular Weight	499.46

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