2226742-52-3

2226742-52-3 structure

Name: Itepekimab
Chemical Name: Itepekimab
CAS Number: 2226742-52-3
Molecular Formula:
Molecular Weight:
Catalog: Signaling Pathways Immunology/Inflammation Interleukin Related
Create Date: 2023-03-11 22:10:03
Modify Date: 2024-04-08 23:10:58
Itepekimab (REGN-3500; SAR-440340) is a monoclonal antibody of IL-33. Itepekimab reduces airway inflammation and related tissue damage in previous clinical studies. Itepekimab has clinical activity in asthma and has potential role in chronic obstructive pulmonary disease (COPD) and pediatric atopic dermatitis (AD)[1][2][3][4].

Name	Itepekimab

Description	Itepekimab (REGN-3500; SAR-440340) is a monoclonal antibody of IL-33. Itepekimab reduces airway inflammation and related tissue damage in previous clinical studies. Itepekimab has clinical activity in asthma and has potential role in chronic obstructive pulmonary disease (COPD) and pediatric atopic dermatitis (AD)[1][2][3][4].
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> Interleukin Related Research Areas >> Inflammation/Immunology
In Vitro	Itepekimab 降低了戒烟者血液中嗜酸性粒细胞数[5]。
References	[1]. Wechsler ME, et al. Efficacy and Safety of Itepekimab in Patients with Moderate-to-Severe Asthma. N Engl J Med. 2021 Oct 28;385(18):1656-1668. [2]. Rabe KF, et al. Safety and efficacy of itepekimab in patients with moderate-to-severe COPD: a genetic association study and randomised, double-blind, phase 2a trial. Lancet Respir Med. 2021 Nov;9(11):1288-1298. [3]. Kosloski MP, et al. Pharmacokinetics and pharmacodynamics of itepekimab in healthy adults and patients with asthma: Phase I first-in-human and first-in-patient trials. Clin Transl Sci. 2022 Feb;15(2):384-395. [4]. Scott JB, et al. Novel treatments for pediatric atopic dermatitis. Curr Opin Pediatr. 2021 Aug 1;33(4):392-401. [5]. Singh D. IL-33 in COPD: the hunt for responder subgroups. Lancet Respir Med. 2022 May;10(5):425-426.

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