1450882-18-4
1450882-18-4 structure
- Name: Asunercept
- Chemical Name: Asunercept
- CAS Number: 1450882-18-4
- Molecular Formula:
- Molecular Weight:
- Catalog: Research Areas Cancer
- Create Date: 2023-02-02 13:19:10
- Modify Date: 2024-01-11 17:49:18
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Asunercept (APG101; CAN008) is a soluble CD95-Fc fusion protein targeting FASLG (CD95L). Asunercept disrupts CD95/CD95L signaling by selectively binding to CD95L. Asunercept can be used in the research of glioblastoma multiforme (GBM), myelodysplastic syndrome (MDS), and graft-versus-host disease (GvHD)[1][2][3].
| Name | Asunercept |
|---|
| Description | Asunercept (APG101; CAN008) is a soluble CD95-Fc fusion protein targeting FASLG (CD95L). Asunercept disrupts CD95/CD95L signaling by selectively binding to CD95L. Asunercept can be used in the research of glioblastoma multiforme (GBM), myelodysplastic syndrome (MDS), and graft-versus-host disease (GvHD)[1][2][3]. |
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| Related Catalog | |
| Target |
CD95L[1][2][3]. |
| In Vitro | Asunercept (APG101; 0-100 µg/mL; preincubation for 30 min) 能特异性中和重组 CD95L 的促凋亡活性[1]。 Asunercept (0.2, 2, 20 µg/mL; 72 h) 能够干扰 CD95 诱导的胶质瘤细胞的迁移/侵袭[1]。 Apoptosis Analysis[1] Cell Line: Jurkat A3 cells (APG293-induced) Concentration: 0-100 µg/mL Incubation Time: 30 min (preincubation) Result: Completely neutralized APG293-induced apoptosis. Cell Invasion Assay[1] Cell Line: U87-MG cells (CD95L knockdown; APG293-induced) Concentration: 0.2, 2, 20 µg/mL Incubation Time: 72 h Result: Blocked APG293 induced invasion of U87 cells (CD95L knockdown). |
| References |
| No Any Chemical & Physical Properties |