2640224-48-0
2640224-48-0 structure
- Name: Nepuvibart
- Chemical Name: Nepuvibart
- CAS Number: 2640224-48-0
- Molecular Formula:
- Molecular Weight:
- Catalog: Signaling Pathways Anti-infection SARS-CoV
- Create Date: 2023-01-25 11:01:55
- Modify Date: 2024-04-05 21:53:47
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Nepuvibart (ZRC3308-B10) is an anti-SARS-CoV-2 monoclonal antibody (IgG1 type). Nepuvibart shows good binding affinity to a non-competing epitope on the RBD of the SARS-CoV-2 spike protein. Nepuvibart can be used in combination with ZRC3308-A7 (HY-145642) at a ratio of 1:1, which is effective for the prevention of COVID-19 and the early stage of COVID-19 before the development of severe disease[1].
| Name | Nepuvibart |
|---|
| Description | Nepuvibart (ZRC3308-B10) is an anti-SARS-CoV-2 monoclonal antibody (IgG1 type). Nepuvibart shows good binding affinity to a non-competing epitope on the RBD of the SARS-CoV-2 spike protein. Nepuvibart can be used in combination with ZRC3308-A7 (HY-145642) at a ratio of 1:1, which is effective for the prevention of COVID-19 and the early stage of COVID-19 before the development of severe disease[1]. |
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| Related Catalog | |
| Target |
SARS-CoV-2[1]. |
| In Vitro | Nepuvibart (ZRC3308-B10; 0-5×105 ng/mL) shows virus neutralizing ability in VeroE6/Vero CCL81 (SARS-CoV-2 infection model) cells, when in combination with ZRC3308-A7 (ratio 1:1)[1]. Nepuvibart neutralizes SARS-CoV-2 variants B.1.1.7, B.1.351, B.1.617.2, and B.1.617.2AY.1 in vitro, when in combination with ZRC3308-A7 (ratio 1:1) [1]. Nepuvibart binds to the RBD of SARS-CoV-2 S1 protein[1]. Cell Viability Assay[1] Cell Line: VeroE6/Vero CCL81 cells (SARS-CoV-2 infection model) Concentration: 0-5×105 ng/mL (in combination with ZRC3308-A7) Incubation Time: 72 h Result: Showed potent neutralization activity with an IC50 of 0.1283 ng/mL. |
| In Vivo | Nepuvibart (ZRC3308-B10; 0.5, 2.5, 25 mg/kg; 48 h prior to the SARS-CoV-2 infection) effectively prevents SARS-CoV-2 infection in syrian hamster, when in combination with ZRC3308-A7 (ratio 1:1)[1]. Nepuvibart (0.5, 2.5, 25 mg/kg; i.p.; single) shows the serum levels remaines constant without much reduction for up to 7 days, in syrian hamster [1]. Animal Model: Female syrian hamster (7 to 10-week-old; SARS-CoV-2 infection model)[1]. Dosage: 0.5, 2.5, 25 mg/kg Administration: Intraperitoneal injection; 48 h prior to the SARS-CoV-2 infection Result: Prevented SARS-CoV-2 infection when in combination with ZRC3308-A7. |
| References |
| No Any Chemical & Physical Properties |