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2767003-71-2

2767003-71-2 structure

2767003-71-2 structure

Name: METTL3-IN-3
Chemical Name: METTL3-IN-3
CAS Number: 2767003-71-2
Molecular Formula: C₂₆H₂₈BrFN₆O₂
Molecular Weight: 555.44
Catalog: Research Areas Others
Create Date: 2023-05-21 19:38:35
Modify Date: 2024-01-20 17:45:41
METTL3-IN-3 (compound 11) is a polyheterocyclic compound, acts as METTL3 inhibitor[1].

Name	METTL3-IN-3

Description	METTL3-IN-3 (compound 11) is a polyheterocyclic compound, acts as METTL3 inhibitor[1].
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others
Target	METTL3[1]
In Vitro	METTL3，即甲基转移酶样 3，是 N6-甲基腺苷 (m6A) 唯一的催化亚基。METTL3 参与真核 mRNA 中内部腺苷残基的转录后甲基化，形成 m6A。m6A 是最丰富的 mRNA 修饰，因此 METTL3 在多种癌症类型中发挥关键作用，或依赖于或不依赖于其 m6A RNA 甲基转移酶活性[2]。
References	[1]. Blackaby WP, et al. Preparation of polyheterocyclic compounds as METTL3 inhibitors: World Intellectual Property Organization, WO2021111124[P]. 2021-06-10. [2]. Zeng C, et al. Roles of METTL3 in cancer: mechanisms and therapeutic targeting. J Hematol Oncol. 2020 Aug 27;13(1):117.

Molecular Formula	C₂₆H₂₈BrFN₆O₂
Molecular Weight	555.44

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