2272975-74-1

2272975-74-1 structure

Name: IONIS-FB-LRx
Chemical Name: IONIS-FB-LRx
CAS Number: 2272975-74-1
Molecular Formula:
Molecular Weight:
Catalog: Signaling Pathways Immunology/Inflammation Complement System
Create Date: 2023-01-13 16:20:32
Modify Date: 2025-08-25 13:05:29
IONIS-FB-LRx is a specific antisense oligonucleotide (ASO) targeting complement factor B (CFB). IONIS-FB-LRx effectively reduces circulating levels of CFB. IONIS-FB-LRx can be used for geographic atrophy (GA) research[1][2].

Name	IONIS-FB-LRx

Description	IONIS-FB-LRx is a specific antisense oligonucleotide (ASO) targeting complement factor B (CFB). IONIS-FB-LRx effectively reduces circulating levels of CFB. IONIS-FB-LRx can be used for geographic atrophy (GA) research[1][2].
Related Catalog	Research Areas >> Others Signaling Pathways >> Immunology/Inflammation >> Complement System
Target	Complement factor B (CFB)[1]
In Vivo	IONIS-FB-Lrx is administered by subcutaneous injection every four weeks and targets CFB’s hepatic expression[2].
References	[1]. Dreismann AK, et al. Gene targeting as a therapeutic avenue in diseases mediated by the complement alternative pathway. Immunol Rev. 2022 Nov 12. [2]. Mahmoudzadeh R, et al. Emerging treatments for geographic atrophy in age-related macular degeneration. Curr Opin Ophthalmol. 2021 May 1;32(3):294-300.

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