945228-49-9
945228-49-9 structure
- Name: Citatuzumab bogatox
- Chemical Name: Citatuzumab bogatox
- CAS Number: 945228-49-9
- Molecular Formula:
- Molecular Weight:
- Catalog: Signaling Pathways Apoptosis Apoptosis
- Create Date: 2023-01-11 21:44:03
- Modify Date: 2024-04-06 17:47:42
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Citatuzumab bogatox (VB6-845) is recombinant immunotoxin that composed of Fab fragment of humanized antibody targeting EpCAM and a modified cytotoxin bouganin. Citatuzumab bogatox binds to and selectively induces Apoptosis in EpCAM-positive cell lines and shows good activity in EpCAM-positive human tumour xenograft models[1][2][3].
| Name | Citatuzumab bogatox |
|---|
| Description | Citatuzumab bogatox (VB6-845) is recombinant immunotoxin that composed of Fab fragment of humanized antibody targeting EpCAM and a modified cytotoxin bouganin. Citatuzumab bogatox binds to and selectively induces Apoptosis in EpCAM-positive cell lines and shows good activity in EpCAM-positive human tumour xenograft models[1][2][3]. |
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| Related Catalog | |
| In Vitro | Citatuzumab bogatox (0-100 nM; 5 days) 抑制 NIH:OVCAR-3 和 CAL-27 细胞的生长，IC50 值均为 3 nM[1]。 Citatuzumab bogatox内化到 EpCAM 表达细胞的细胞质中，然后释放的 Bouganin 通过核糖体失活抑制蛋白质合成，导致癌细胞凋亡[2]。 Cell Viability Assay[1] Cell Line: NIH:OVCAR-3 and CAL-27 cells Concentration: 0-100 nM Incubation Time: 5 days Result: Exhibited an IC50 of 3 nM to against the EpCAM-positive cell lines. |
| In Vivo | Citatuzumab bogatox (10, 20 mg/kg; i.v./i.p.) 抑制小鼠体内肿瘤生长[1]。 Citatuzumab bogatox (10, 20 mg/kg) 在小鼠体内显示很好的耐受性，并无任何明显的体重下降[1]。 Animal Model: Female CB.17 SCID mice (~20 g; OVCAR-3 Xenograft model)[1]. Dosage: 10, 20 mg/kg Administration: Tail vein (until day 26 when due to tail swelling, route of administration was changed to intraperitoneal for the remaining 7 doses); single daily for 5 consecutive days for 3 weeks and then received maintenance dosing on Monday and Friday for 4 weeks. Result: Showed an average of 40 mm3 (control group was 750 mm3) on day 75, and with 3/15 mice being tumor free, when at 10 mg/kg. Almost completely inhibited tumour growth when at 20 mg/kg. |
| References |
| No Any Chemical & Physical Properties |