1518996-49-0
1518996-49-0 structure
- Name: Andecaliximab
- Chemical Name: Andecaliximab
- CAS Number: 1518996-49-0
- Molecular Formula:
- Molecular Weight:
- Catalog: Signaling Pathways Metabolic Enzyme/Protease MMP
- Create Date: 2023-01-11 19:20:25
- Modify Date: 2024-01-09 11:06:42
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Andecaliximab is a recombinant chimeric IgG4 monoclonal antibody (mAb) targets matrix metalloproteinase 9 (MMP9). Andecaliximab shows the antifibrotic efficacy in idiopathic pulmonary fibrosis mouse models. Andecaliximab can be used for the research of gastric adenocarcinoma and idiopathic pulmonary fibrosis (IPF)[1][2].
| Name | Andecaliximab |
|---|
| Description | Andecaliximab is a recombinant chimeric IgG4 monoclonal antibody (mAb) targets matrix metalloproteinase 9 (MMP9). Andecaliximab shows the antifibrotic efficacy in idiopathic pulmonary fibrosis mouse models. Andecaliximab can be used for the research of gastric adenocarcinoma and idiopathic pulmonary fibrosis (IPF)[1][2]. |
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| Related Catalog | |
| In Vitro | Andecaliximab 增加血清中 IL-7 的水平[1]。 Andecaliximab (50 μg/mL；24 h)减少 ABC 类细胞系的 SMAD2 磷酸化 (pSMAD2)[2]。 |
| In Vivo | Andecaliximab 改善肿瘤浸润 T 细胞内 T 细胞受体 (TCR) 的多样性[1]。 Andecaliximab (20 mg/kg；腹腔注射，单次) 在特发性肺纤维化的人源 NSG 小鼠模型中显示出抗纤维化功效[2]。 Animal Model: Humanized nonobese diabetic, SCID, IL-2 receptor g (NSG) mouse model of IPF[2] Dosage: 20 mg/kg Administration: Intraperitoneal injection; 20 mg/kg, once a week for once Result: Decreased SMAD2 phosphorylation and increased surfactant protein C. Reduced MMP9+ cells, including MMP9+, CCR10+ and MMP9+CD45- and EpCAM+CCR10+ subpopulations. |
| References |
| No Any Chemical & Physical Properties |