564479-79-4
564479-79-4 structure
- Name: RXPA 380
- Chemical Name: RXPA 380
- CAS Number: 564479-79-4
- Molecular Formula: C33H36N3O7P
- Molecular Weight: 617.63
- Catalog: Signaling Pathways Metabolic Enzyme/Protease Angiotensin-converting Enzyme (ACE)
- Create Date: 2022-12-09 08:03:00
- Modify Date: 2024-09-19 11:28:24
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RXPA 380 is a C-terminal specific angiotensin-converting enzyme (ACE) inhibitor with a Ki of 3 nM. RXPA 380 inhibits C-domain mutants of human recombinant ACE with an IC50 of 2.5 nM[1].
| Name | RXPA 380 |
|---|
| Description | RXPA 380 is a C-terminal specific angiotensin-converting enzyme (ACE) inhibitor with a Ki of 3 nM. RXPA 380 inhibits C-domain mutants of human recombinant ACE with an IC50 of 2.5 nM[1]. |
|---|---|
| Related Catalog | |
| Target |
Ki: 3 nM (C-terminal ACE), 10 μM (N-terminal ACE)[1] IC50: 2.5 nM (C-domain mutants of human recombinant ACE), 10 μM (N-domain mutants of human recombinant ACE)[1] |
| In Vitro | RXPA 380 shows Ki(app) values of 12 nM and 12 μM for the C- and N-domain of mouse somatic ACE[1]. |
| In Vivo | RXPA 380 (0.9-30 mg/kg; i.v.; once) inhibits ACE activity in mice[1]. Animal Model: Male C57BL6/J mice[1] Dosage: 0.9, 3, 10, and 30 mg/kg Administration: Intravenous infuse for 30 minutes Result: Induced a dose-dependent decrease of the Ang II/Ang I ratio. Blocked the cleavage of exogenously administered bradykinin. |
| Molecular Formula | C33H36N3O7P |
|---|---|
| Molecular Weight | 617.63 |