2840581-32-8
2840581-32-8 structure
- Name: MRS4719
- Chemical Name: MRS4719
- CAS Number: 2840581-32-8
- Molecular Formula: C26H13N5O3S.C6H15N
- Molecular Weight: 504.60
- Catalog: Signaling Pathways Membrane Transporter/Ion Channel P2X Receptor
- Create Date: 2022-12-15 17:10:45
- Modify Date: 2024-04-03 11:51:45
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MRS4719 is a potent P2X4 receptor antagonist with an IC50 value of 0.503 μM for human P2X4 receptor. MRS4719 can reduce infarct volume and reduce brain atrophy, showing neuroprotective and neuro-rehabilitative activities in ischemic stroke model. MRS4719 also reduces ATP-induced [Ca2+]i influx in primary human monocyte-derived macrophages. MRS4719 can be used to research ischemic stroke[1].
| Name | MRS4719 |
|---|
| Description | MRS4719 is a potent P2X4 receptor antagonist with an IC50 value of 0.503 μM for human P2X4 receptor. MRS4719 can reduce infarct volume and reduce brain atrophy, showing neuroprotective and neuro-rehabilitative activities in ischemic stroke model. MRS4719 also reduces ATP-induced [Ca2+]i influx in primary human monocyte-derived macrophages. MRS4719 can be used to research ischemic stroke[1]. |
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| Related Catalog | |
| Target |
IC50: 0.503 μM (P2X4 receptor)[1] |
| In Vitro | MRS4719 (compound 21u) (0.1, 0.3, 0.6, 1.0 and 3.0 μM; 15 min) inhibits P2X4R-mediated Ca2+ influx in human subjects[1]. |
| In Vivo | MRS4719 (compound 21u) (0.5-3 mg/kg; 3 days continuous infusion with an Alzet minipump) reduce infarct volume and reduced brain atrophy; does not improve motor coordination and balance as assessed using rotarod; improves learning and memory after stroke[1]. Animal Model: Male and female young C57B/6 mice (8-12 weeks; induced transient focal cerebral ischemia by a 60 min right middle cerebral artery occlusion)[1] Dosage: 0.5, 1.5 and 3 mg/kg Administration: 3 days continuous infusion with an Alzet minipump Result: Caused significant neuroprotection using total hemispheric infarct volume size at doses 1.5 and 3.0 mg/kg. Animal Model: Middle-aged C57B/6 mice (11-12 month-old; induced transient focal cerebral ischemia by a 60 min right middle cerebral artery occlusion)[1] Dosage: 1.5 and 3 mg/kg Administration: 3 days continuous infusion with an Alzet minipump Result: Did not improve motor coordination and balance as assessed using rotarod. Animal Model: Middle-aged C57B/6 mice (11-12 month-old; induced transient focal cerebral ischemia by a 60 min right middle cerebral artery occlusion)[1] Dosage: 3 mg/kg Administration: 3 days continuous infusion with an Alzet minipump Result: Improved dose-dependently learning and memory after stroke and reached statistical significance at a dose of 3 mg/kg. |
| Molecular Formula | C26H13N5O3S.C6H15N |
|---|---|
| Molecular Weight | 504.60 |