229180-41-0
229180-41-0 structure
- Name: Contulakin G
- Chemical Name: Contulakin G
- CAS Number: 229180-41-0
- Molecular Formula: C88H140N20O37
- Molecular Weight: 2070.17
- Catalog: Signaling Pathways GPCR/G Protein Neurotensin Receptor
- Create Date: 2022-12-04 09:01:45
- Modify Date: 2024-01-12 15:48:27
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Contulakin G is an O-glycosylated invertebrate neurotensin. Contulakin-G is a weaker agonist for the neurotensin receptor. Contulakin G is also a potent antinociceptive agent[1][2].
| Name | Contulakin G |
|---|
| Description | Contulakin G is an O-glycosylated invertebrate neurotensin. Contulakin-G is a weaker agonist for the neurotensin receptor. Contulakin G is also a potent antinociceptive agent[1][2]. |
|---|---|
| Related Catalog | |
| In Vivo | Contulakin G exhibits potent analgesic activity in three pain models in rats following intrathecal delivery, namely in tail-flick (acute pain), formalin test, and CFA-induced allodynia inflammatory pain[1]. Contulakin G (0-3 nmoL, Intrathecally) significantly decreases flinching behavior in rats[2]. Contulakin G (50-500 nmoL, Intrathecally) produces a dose-dependent increase in the thermally evoked skin twitch latency by 30 min after administration in dogs[2]. Animal Model: Male Holtzman rats (300-375 g)[2] Dosage: 0.03, 0.1, 0.3, and 3 nmol Administration: Intrathecally, administered as a 10-μL bolus followed by a 10-μL saline flush Result: Produced a significant decrease in flinching in all phases of the formalin test in rats. Animal Model: Purpose-bred beagle dogs (9-12 kg)[2] Dosage: 50, 150, or 500 nmol Administration: Intrathecally Result: Produced a dose-dependent increase in the thermally evoked skin twitch latency at 30 min after dosing in dogs, which reached statistical difference as compared to vehicle at 500 nmol. |
| Molecular Formula | C88H140N20O37 |
|---|---|
| Molecular Weight | 2070.17 |