1480724-61-5
1480724-61-5 structure
- Name: vosoritide
- Chemical Name: Vosoritide
- CAS Number: 1480724-61-5
- Molecular Formula: C176H290N56O51S3
- Molecular Weight: 4102.73
- Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK FGFR
- Create Date: 2022-11-14 19:07:55
- Modify Date: 2024-01-16 16:19:20
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Vosoritide (BMN 111) is a modified recombinant CNP (C-type natriuretic peptide) analogue, binds to NPR-B (natriuretic peptide receptor type B) and reduces the activity of FGFR3 (fibroblast growth factor receptor 3). Vosoritide can be used in achondroplasia and dwarfism research[1][2][3].
| Name | Vosoritide |
|---|
| Description | Vosoritide (BMN 111) is a modified recombinant CNP (C-type natriuretic peptide) analogue, binds to NPR-B (natriuretic peptide receptor type B) and reduces the activity of FGFR3 (fibroblast growth factor receptor 3). Vosoritide can be used in achondroplasia and dwarfism research[1][2][3]. |
|---|---|
| Related Catalog | |
| In Vitro | Vosoritide (0.1 μM; 1 h) decreases NPR2 phosphorylation in chondrocytes[2]. Vosoritide (0.1 μM; 6 d) improves chondrocyte differentiation and increases the proliferative growth plate area of cultured Fgfr3Y367C/+ femurs[2]. Vosoritide (10 μM; overnight) reduces ERK1/2 activation in ACH growth-plate chondrocytes[3]. Western Blot Analysis[2] Cell Line: Chondrocyte cultures Concentration: 0.1 μM Incubation Time: 1 hour Result: Led to reduction in NPR2 phosphorylation. Western Blot Analysis[3] Cell Line: Chondrocyte Concentration: 10 μM Incubation Time: Overnight Result: Prevented FGF-mediated increase in ERK1/2 phosphorylation. |
| In Vivo | Vosoritide (subcutaneous injection; 800 μg/kg; once daily; 20 d) treatment leads to improvement in skeletal parameters in Fgfr3 gain-of-function mutation mouse[3]. Animal Model: Fgfr3Y367C/+ mice[3] Dosage: 800 μg/kg Administration: Subcutaneous injection; 800 μg/kg; once daily; 20 days Result: Observed phenotypic changes including flattening of the skull, elongation of the snout, improvement of the anterior crossbite, larger paws and digits, and longer and straightened tibias and femurs. |
| Molecular Formula | C176H290N56O51S3 |
|---|---|
| Molecular Weight | 4102.73 |