541502-14-1
541502-14-1 structure
- Name: Siltuximab
- Chemical Name: Siltuximab
- CAS Number: 541502-14-1
- Molecular Formula:
- Molecular Weight:
- Catalog: Signaling Pathways Immunology/Inflammation Interleukin Related
- Create Date: 2022-11-21 21:23:55
- Modify Date: 2024-01-15 00:50:21
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Siltuximab is an anti-IL-6 (interleukin-6) monoclonal antibody, and shows antitumor activity. Siltuximab can be used in Multicentric Castleman's Disease (MCD) and COVID-19 research[1][2][3].
| Name | Siltuximab |
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| Description | Siltuximab is an anti-IL-6 (interleukin-6) monoclonal antibody, and shows antitumor activity. Siltuximab can be used in Multicentric Castleman's Disease (MCD) and COVID-19 research[1][2][3]. |
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| Related Catalog | |
| In Vivo | Siltuximab (intraperitoneal injection; 10 mg/kg; 3 times per week) inhibits the growth of lung cancer cells in xenograft mouse model[1]. Siltuximab (intraperitoneal injection; 20 mg/kg; twice per week; 6 w) inhibits the growth of MCF-7 tumor in xenograft model[4]. Animal Model: Female CD-1 nu/nu mice injected with H1650 (adenocarcinoma), H322 (adenocarcinoma), or H157 (squamous) cells[1] Dosage: 10 mg/kg Administration: Intraperitoneal injection; 10 mg/kg; 3 times per week Result: Repressed PY-STAT3 levels stimulated by IL-6 in H322 cells. Repressed PY-STAT3 levels in H1650 cells. Inhibited the growth of tumors with H322 and CAF cells. Inhibited the growth of tumors with H1650 and CAF cells. Animal Model: Female NOD-SCID mice with MCF-7 tumor[4] Dosage: 20 mg/kg Administration: Intraperitoneal injection; 20 mg/kg; twice per week; 6 weeks Result: Blocked MCF-7 engraftment, induced regressions in 90% of tumors. |
| Storage condition | 2-8°C |
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