1619927-64-8

1619927-64-8 structure

Name: Momelotinib-2,2,6,6-d4
Chemical Name: Momelotinib-2,2,6,6-d4
CAS Number: 1619927-64-8
Molecular Formula: C₂₃H₁₈D₄N₆O₂
Molecular Weight: 418.48
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2022-11-21 19:05:57
Modify Date: 2024-04-06 20:23:18
Momelotinib-2,2,6,6-d4 (CYT387-2,2,6,6-d4) is the deuterium labeled Momelotinib (HY-10961). Momelotinib (CYT387) is an orally acitve and ATP-competitive JAK1/JAK2 inhibitor with IC50s of 11 nM and 18 nM, respectively[1][2].

Name	Momelotinib-2,2,6,6-d4

Description	Momelotinib-2,2,6,6-d4 (CYT387-2,2,6,6-d4) is the deuterium labeled Momelotinib (HY-10961). Momelotinib (CYT387) is an orally acitve and ATP-competitive JAK1/JAK2 inhibitor with IC50s of 11 nM and 18 nM, respectively[1][2].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> JAK/STAT Signaling >> JAK Signaling Pathways >> Epigenetics >> JAK Signaling Pathways >> Stem Cell/Wnt >> JAK Signaling Pathways >> Autophagy >> Autophagy
Target	JAK1:11 nM (IC50) JAK2:18 nM (IC50)
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Molecular Formula	C₂₃H₁₈D₄N₆O₂
Molecular Weight	418.48