93076-87-0
93076-87-0 structure
- Name: JNJ-3790339
- Chemical Name: JNJ-3790339
- CAS Number: 93076-87-0
- Molecular Formula: C30H33N3OS
- Molecular Weight: 483.67
- Catalog: Research Areas Cancer
- Create Date: 2022-11-21 11:58:26
- Modify Date: 2024-04-03 16:27:47
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JNJ-3790339, a Ritanserin (HY-10791) analog, is a potent and selective diacylglycerol kinase (DGKα) inhibitor with an IC50 of 9.6 μM. JNJ-3790339 has induction of toxicity in malignant cells, and improves ability to upregulate T cell activation[1].
| Name | JNJ-3790339 |
|---|
| Description | JNJ-3790339, a Ritanserin (HY-10791) analog, is a potent and selective diacylglycerol kinase (DGKα) inhibitor with an IC50 of 9.6 μM. JNJ-3790339 has induction of toxicity in malignant cells, and improves ability to upregulate T cell activation[1]. |
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| Related Catalog | |
| Target |
IC50: 9.6 μM (DGKα)[1] |
| In Vitro | JNJ-3790339 (5-40 μM; 48 h) exhibits cytotoxic efficacy against A375, U251 and Jurkat T[1]. JNJ-3790339 (5 μM; 6 h) promotes activation of primary murine T cells[1]. Cell Cytotoxicity Assay[1] Cell Line: A375, U251 and Jurkat T Concentration: 5, 15, 25 and 40 μM Incubation Time: 48 h Result: Exhibited cytotoxic efficacy against cancer cells in a dose-dependent manner. RT-PCR[1] Cell Line: Jurkat T Concentration: 5 μM Incubation Time: 6 h Result: Displayed high activation response with significantly increased CD69 and TNFα expression. |
| Molecular Formula | C30H33N3OS |
|---|---|
| Molecular Weight | 483.67 |