914009-86-2
914009-86-2 structure
- Name: Glepaglutide
- Chemical Name: Glepaglutide
- CAS Number: 914009-86-2
- Molecular Formula: C197H325N53O55
- Molecular Weight: 4316.08
- Catalog: Research Areas Inflammation/Immunology
- Create Date: 2022-11-21 19:12:12
- Modify Date: 2024-04-12 17:31:26
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Glepaglutide (ZP1848), a long-acting GLP-2 analogue, is a potent GLP-2R agonist. Glepaglutide reduces faecal output and increases intestinal absorption. Glepaglutide alleviates small intestinal inflammation. Glepaglutide can be used in the research of inflammatory bowel disease (IBD) and Crohn’s disease[1][2][3].
| Name | Glepaglutide |
|---|
| Description | Glepaglutide (ZP1848), a long-acting GLP-2 analogue, is a potent GLP-2R agonist. Glepaglutide reduces faecal output and increases intestinal absorption. Glepaglutide alleviates small intestinal inflammation. Glepaglutide can be used in the research of inflammatory bowel disease (IBD) and Crohn’s disease[1][2][3]. |
|---|---|
| Related Catalog | |
| Target |
GLP-2R[3] |
| In Vivo | Glepaglutide (200 and 400 nmol/kg, s.c., twice a day for 14 days) shows intestinotrophic effect in rats with small intestinal inflammation[3]. Animal Model: Rats with Indomethacin (HY-14397)-induced small intestinal inflammation[3] Dosage: 200 and 400 nmol/kg Administration: Subcutaneousinjection (s.c.), twice a day for 14 days. Result: Increased plasma citrulline concentration. Increased small intestinal mass. Decreased small intestinal concentrations of the inflammatory marker (AGP and MPO). |
| Molecular Formula | C197H325N53O55 |
|---|---|
| Molecular Weight | 4316.08 |