1621535-90-7

1621535-90-7 structure

1621535-90-7 structure

Name: UCM-1336
Chemical Name: Propanamide, 3,3'-(octylimino)bis[N-phenyl-
CAS Number: 1621535-90-7
Molecular Formula: C₂₆H₃₇N₃O₂
Molecular Weight: 423.59
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2022-11-01 19:25:50
Modify Date: 2023-10-20 19:26:29
UCM-1336 is a potent ICMT inhibitor, with an IC50 of 2 μM. UCM-1336 induces mislocalization of endogenous Ras, decreases Ras activation and induces cell death by autophagy and apoptosis[1].

Name	Propanamide, 3,3'-(octylimino)bis[N-phenyl-

Description	UCM-1336 is a potent ICMT inhibitor, with an IC50 of 2 μM. UCM-1336 induces mislocalization of endogenous Ras, decreases Ras activation and induces cell death by autophagy and apoptosis[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Autophagy >> Autophagy
Target	IC50: 2 μM (2 μM)[1].
References	[1]. Nagore Marín-RamosA, Potent Isoprenylcysteine Carboxylmethyltransferase (ICMT) Inhibitor Improves Survival in Ras-Driven Acute Myeloid Leukemia. J Med Chem. 2019 Jul 11;62(13):6035-6046.

Molecular Formula	C₂₆H₃₇N₃O₂
Molecular Weight	423.59