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2271269-01-1

2271269-01-1 structure
2271269-01-1 structure
  • Name: UBX1325
  • Chemical Name: UBX1325
  • CAS Number: 2271269-01-1
  • Molecular Formula: C53H59ClF3N6O10PS3
  • Molecular Weight: 1159.69
  • Catalog: Signaling Pathways Apoptosis Apoptosis
  • Create Date: 2022-11-21 18:12:38
  • Modify Date: 2025-08-25 13:50:36
  • UBX1325 is an Bcl-xL inhibitor that promotes apoptosis in senescent cells. UBX1325 is a potent anti-aging agent that can be used in studies of age-related eye diseases such as diabetic macular oedema (DME), age-related macular degeneration (AMD) and diabetic retinopathy (DR)[1].

Name UBX1325
Description UBX1325 is an Bcl-xL inhibitor that promotes apoptosis in senescent cells. UBX1325 is a potent anti-aging agent that can be used in studies of age-related eye diseases such as diabetic macular oedema (DME), age-related macular degeneration (AMD) and diabetic retinopathy (DR)[1].
Related Catalog
In Vitro UBX1325 leads to a decrease in the anti-apoptotic Bcl-xL:Bim complex in retina by intravitreal (IVT) injection administration in oxygen induced retinopathy (OIR) C57BL/6 mice model[1]. UBX1325 can cause a decrease in retinal vascular permeability and promote retinal neovascularization in streptozotocin (STZ)-induced retinopathy mice model[1].
References

[1]. Pamela Tsuruda, et al. UBX1325, a small molecule inhibitor of Bcl-xL, attenuates vascular dysfunction in two animal models of retinopathy. Investigative Ophthalmology & Visual Science June 2021,Volume 62, Issue 8

Molecular Formula C53H59ClF3N6O10PS3
Molecular Weight 1159.69
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