1801185-08-9
1801185-08-9 structure
- Name: SR12418
- Chemical Name: SR12418
- CAS Number: 1801185-08-9
- Molecular Formula: C31H30FNO3
- Molecular Weight: 483.57
- Catalog: Research Areas Inflammation/Immunology
- Create Date: 2022-11-01 16:48:15
- Modify Date: 2024-04-05 19:17:25
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SR12418 is a REV-ERB-specific synthetic ligand with IC50s of 68 nM and 119 nM for REV-ERBα and REV-ERBβ, respectively. SR12418 can be used in experimental autoimmune encephalomyelitis (EAE) and colitis research[1][2].
| Name | SR12418 |
|---|
| Description | SR12418 is a REV-ERB-specific synthetic ligand with IC50s of 68 nM and 119 nM for REV-ERBα and REV-ERBβ, respectively. SR12418 can be used in experimental autoimmune encephalomyelitis (EAE) and colitis research[1][2]. |
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| Related Catalog | |
| Target |
IC50: 68 nM (REV-ERBα) and 119 nM (REV-ERBβ)[1] |
| In Vitro | SR12418 (5 μM; 96 h) inhibits the growth of TH17 cells[1]. SR12418 (5 and 10 μM; 4 d) inhibits cell differentiation under TH17 polarizing conditions[1]. RT-PCR[1] Cell Line: TH17 cells Concentration: 5 μM Incubation Time: 96 hours Result: Repressed TH17-mediated gene expression and Nfil3. Cell Differentiation Assay[1] Cell Line: Mouse CD4+ T cells Concentration: 5 and 10 μM Incubation Time: 4 days Result: Inhibited TH17 cell differentiation in a dose-dependent manner. |
| In Vivo | SR12418 (intraperitoneal injection; 50 mg/kg; twice a day) suppresses the development and severity of experimental autoimmune encephalomyelitis[1]. SR12418 (intraperitoneal injection; 50 mg/kg; twice a day; begin at day 18 post-immunization) shows effects in intervention studies of relapsing-remitting experimental autoimmune encephalomyelitis[1]. Animal Model: C57BL/6 mice inducing experimental autoimmune encephalomyelitis (EAE)[1] Dosage: 50 mg/kg Administration: Intraperitoneal injection; 50 mg/kg; twice a day Result: Diminished the incidence of disease with approximately 20% mice developing disease. Showed no overt signs of toxicity. Animal Model: PLP139-151-induced relapsing-remitting EAE (R-EAE) in SJL/J mice[1] Dosage: 50 mg/kg Administration: Intraperitoneal injection; 50 mg/kg; twice a day; begin at day 18 post-immunization Result: Resulted in a significant reduction in the relapse severity compared to the vehicle control. Showed a significant decrease in the frequency and number of CD4+ and CD8+ effector cells (CD44hi). |
| References |
| Molecular Formula | C31H30FNO3 |
|---|---|
| Molecular Weight | 483.57 |