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503860-50-2

503860-50-2 structure

503860-50-2 structure

Name: Shishijimicin A
Chemical Name: Shishijimicin A
CAS Number: 503860-50-2
Molecular Formula: C₄₆H₅₂N₄O₁₂S₄
Molecular Weight: 981.18
Catalog: Research Areas Cancer
Create Date: 2022-10-10 21:10:37
Modify Date: 2024-04-03 11:07:21
Shishijimicin A is a novel antitumor agent found from the Ascidian Didemnum proliferum. Shishijimicin A shows anti-tumor activity with highly potent cytotoxicities[1][2].

Name	Shishijimicin A

Description	Shishijimicin A is a novel antitumor agent found from the Ascidian Didemnum proliferum. Shishijimicin A shows anti-tumor activity with highly potent cytotoxicities[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
In Vitro	Shishijimicin A (compound 1) (0.47-2.0 pg/mL) shows high cytotoxicity for 3Y1, Hela and P388 cells[1]. Shishijimicin A (0.13-1000 nM) shows high cytotoxicity for MES SA, MES SA DX and HEK 293T cells[2]. Cell Cytotoxicity Assay[1] Cell Line: 3Y1, Hela and P388 cells Concentration: 0.47-2.0 pg/mL Incubation Time: Result: Showed IC50 values of 2.0, 1.8, and 0.47 pg/mL for 3Y1, Hela and P388 cells, respectively. Cell Cytotoxicity Assay[2] Cell Line: MES SA, MES SA DX and HEK 293T cells Concentration: 0.13-1000 nM Incubation Time: Result: Showed IC50 values of 0.13, >1000, and 0.016 nM for MES SA, MES SA DX and HEK 293T cells, respectively.
References	[1]. Naoya Oku, et al. Shishijimicins A-C, novel enediyne antitumor antibiotics from the ascidian Didemnum proliferum(1). J Am Chem Soc. 2003 Feb 26;125(8):2044-5. [2]. K C Nicolaou, et al. Streamlined Total Synthesis of Shishijimicin A and Its Application to the Design, Synthesis, and Biological Evaluation of Analogues thereof and Practical Syntheses of PhthNSSMe and Related Sulfenylating Reagents. J Am Chem Soc. 2018 Sep 26;140(38):12120-12136.

Molecular Formula	C₄₆H₅₂N₄O₁₂S₄
Molecular Weight	981.18

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