2489320-03-6
2489320-03-6 structure
- Name: Protein kinase D inhibitor 1
- Chemical Name: Protein kinase D inhibitor 1
- CAS Number: 2489320-03-6
- Molecular Formula: C19H21N7
- Molecular Weight: 347.42
- Catalog: Signaling Pathways Apoptosis PKD
- Create Date: 2022-10-11 11:07:25
- Modify Date: 2025-08-26 19:39:50
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Protein kinase D inhibitor 1 (compound 17m) is a pan-PKD inhibitor, with IC50 values ranging from 17 to 35 nM. Protein kinase D inhibitor 1 inhibits PKD-dependent cortactin phosphorylation[1].
| Name | Protein kinase D inhibitor 1 |
|---|
| Description | Protein kinase D inhibitor 1 (compound 17m) is a pan-PKD inhibitor, with IC50 values ranging from 17 to 35 nM. Protein kinase D inhibitor 1 inhibits PKD-dependent cortactin phosphorylation[1]. |
|---|---|
| Related Catalog | |
| Target |
PKD3:17 ± 8 nM (IC50) PKD2:35 ± 5 nM (IC50) PKD1:35 ± 10 nM (IC50) |
| In Vitro | Protein kinase D inhibitor 1 (compound 17m) displays excellent PKD2 inhibition with almost no remaining kinase activity at 1 μM[1]. Protein kinase D inhibitor 1 displays only weak antiproliferative activity, and does not significantly affect PANC-1 cell proliferation at a concentration of 5 μM[1]. Protein kinase D inhibitor 1 (0-100 μM, 72 h) shows antitumor activity[1]. Cell Viability Assay[1] Cell Line: LN-229, Capan-1, DND-41, HL-60, Z-138, NCI-H460, HCT-116, K-562 Concentration: 0-100 μM Incubation Time: 72 h Result: Inhibited of tumor cell growth of LN-229, Capan-1, DND-41, HL-60, Z-138, NCI-H460, HCT-116, and K-562, with IC50 values of 80.6 ± 7, 40.7 ± 14.5, 42.7 ± 4.9, 17.9 ± 4.1, 35.3 ± 10.4, >95.8, >100, and >100, respectively. |
| References |
| Molecular Formula | C19H21N7 |
|---|---|
| Molecular Weight | 347.42 |