Shanghai Nianxing Industrial Co., Ltd
China
Product Name: PFM03
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1558598-48-3

1558598-48-3 structure

1558598-48-3 structure

Name: PFM03
Chemical Name: PFM03
CAS Number: 1558598-48-3
Molecular Formula: C₁₄H₁₅NO₂S₂
Molecular Weight: 293.40
Catalog: Research Areas Others
Create Date: 2022-11-21 16:49:35
Modify Date: 2025-11-16 14:22:09
PFM03 is a MRE11 Endonuclease inhibitor. PFM03 regulates DNA double-strand break repair (DSBR) by nonhomologous end-joining (NHEJ)[1].

Name	PFM03

Description	PFM03 is a MRE11 Endonuclease inhibitor. PFM03 regulates DNA double-strand break repair (DSBR) by nonhomologous end-joining (NHEJ)[1].
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others
In Vitro	PFM03 (50-400 μM; 30 min) specifically inhibits MRE11 endonuclease activity[1]. PFM03 (100 μM; 30 min) causes normal DSB repair in G2 (CENPF+) cells[1]. PFM03 (50 μM; 8 h) enhances NHEJ usage but reduces homologous recombination (HR) in cells[1].
References	[1]. Shibata A, et al. DNA double-strand break repair pathway choice is directed by distinct MRE11 nuclease activities. Mol Cell. 2014 Jan 9;53(1):7-18.

Molecular Formula	C₁₄H₁₅NO₂S₂
Molecular Weight	293.40

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