2164447-18-9

2164447-18-9 structure

Name: MurA-IN-2
Chemical Name: MurA-IN-2
CAS Number: 2164447-18-9
Molecular Formula: C₁₂H₂₀ClNO
Molecular Weight: 229.75
Catalog: Signaling Pathways Anti-infection Bacterial
Create Date: 2022-10-21 10:26:01
Modify Date: 2025-08-22 02:58:47
MurA-IN-2 (compound 37), a chloroacetamide fragment containing a primary aliphatic amine, is a potent MurA inhibitor with an IC50 value of 39  μM. MurA-IN-2 has antibacterial activity and inhibits the bacterial cell wall synthesis[1].

Name	MurA-IN-2

Description	MurA-IN-2 (compound 37), a chloroacetamide fragment containing a primary aliphatic amine, is a potent MurA inhibitor with an IC50 value of 39  μM. MurA-IN-2 has antibacterial activity and inhibits the bacterial cell wall synthesis[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial
Target	IC50: 39 μM (MurA)[1]
In Vitro	MurA-IN-2 (compound 37; 128 μg/mL) inhibits bacteria S. aureus ATCC29213 and E. coli ATCC25922 activity[1].
References	[1]. Grabrijan K, et, al. Covalent inhibitors of bacterial peptidoglycan biosynthesis enzyme MurA with chloroacetamide warhead. Eur J Med Chem. 2022 Sep 13; 114752. [2]. Grabrijan K, et, al. Covalent inhibitors of bacterial peptidoglycan biosynthesis enzyme MurA with chloroacetamide warhead. Eur J Med Chem. 2022 Sep 13; 114752.

Molecular Formula	C₁₂H₂₀ClNO
Molecular Weight	229.75