219818-60-7
219818-60-7 structure
- Name: MnTE-2-PyP chloride
- Chemical Name: MnTE-2-PyP chloride
- CAS Number: 219818-60-7
- Molecular Formula: C48H44Cl5MnN8
- Molecular Weight: 965.12
- Catalog: Research Areas Cancer
- Create Date: 2022-11-02 17:49:48
- Modify Date: 2024-04-06 09:42:44
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MnTE-2-PyP (BMX-010) chloride is a ROS scavenger and potent radioprotector. MnTE-2-PyP also is a manganese porphyrin, protects normal prostate tissue from radiation damage. MnTE-2-PyP can be used for the research of diabetic prostate cancer[1].
| Name | MnTE-2-PyP chloride |
|---|
| Description | MnTE-2-PyP (BMX-010) chloride is a ROS scavenger and potent radioprotector. MnTE-2-PyP also is a manganese porphyrin, protects normal prostate tissue from radiation damage. MnTE-2-PyP can be used for the research of diabetic prostate cancer[1]. |
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| Related Catalog | |
| In Vitro | MnTE-2-PyP (30 μM) protects against hyperglycemiainduced cell death after radiation[1]. MnTE-2-PyP (30 μM) decreases expression of NOX4 and a-SMA, one of the major oxidative enzymes and pro-fibrotic molecules respectively[1]. MnTE-2-PyP (30 μM, 5 days) obstructs NF-kB activity by decreasing DNA binding of the p50-p50 homodimer in the irradiated hyperglycemic environment[1]. MnTE-2-PyP (30 μM) increases NRF2 mediated cytoprotection by increasing NRF2 protein expression and DNA binding[1]. Cell Viability Assay[1] Cell Line: PC-3 cells and LNCaP cells Concentration: 30 μM Incubation Time: Result: Enhanced prostate cancer cell death. RT-PCR[1] Cell Line: Human prostate fibroblast cells Concentration: 30 μM Incubation Time: 5 days Result: Significantly decreased NOX4 mRNA expression. Western Blot Analysis[1] Cell Line: Human prostate fibroblast cells Concentration: 30 μM Incubation Time: 24 h Result: Inhibited NOX4 expression and restored NOX2 expression after radiation. Immunofluorescence[1] Cell Line: Human prostate fibroblast cells Concentration: 30 μM Incubation Time: 5 days Result: Enhanced NRF2 levels. |
| In Vivo | MnTE2-PyP decreases tumor volume and increases survival in vivo mouse model of prostate cancer[1]. MnTE-2-PyP reduces blood glucose and inhibits pro-fibrotic signaling in a diabetic model[1]. |
| References |
| Molecular Formula | C48H44Cl5MnN8 |
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| Molecular Weight | 965.12 |