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183488-96-2

183488-96-2 structure

183488-96-2 structure

Name: LasR-IN-4
Chemical Name: LasR-IN-4
CAS Number: 183488-96-2
Molecular Formula: C₁₈H₂₀N₄
Molecular Weight: 292.38
Catalog: Signaling Pathways Anti-infection Bacterial
Create Date: 2022-11-05 12:53:46
Modify Date: 2024-04-03 21:19:30
LasR-IN-4 is a potent LasR inhibitor. LasR-IN-4 can inhibit Pseudomonas aeruginosa and its biofilm formation, pyocyanin production, and rhamnolipids production[1].

Name	LasR-IN-4

Description	LasR-IN-4 is a potent LasR inhibitor. LasR-IN-4 can inhibit Pseudomonas aeruginosa and its biofilm formation, pyocyanin production, and rhamnolipids production[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial
Target	MIC: 56.25 μg/mL (P. aeruginosa)[1]
In Vitro	LasR-IN-4 (compound 3d) has inhibitory activity against P. aeruginosa with MIC of 56.25 μg/mL, and inhibits biofilm formation, pyocyanin production, and rhamnolipids production of 71.70%, 68.70% and 54.00%, respectively[1].
References	[1]. Abd El-Aleam RH, et al. Design and synthesis of novel benzimidazole derivatives as potential Pseudomonas aeruginosa anti-biofilm agents inhibiting LasR: Evidence from comprehensive molecular dynamics simulation and in vitro investigation. Eur J Med Chem. 2022 Aug 5;241:114629.

Molecular Formula	C₁₈H₂₀N₄
Molecular Weight	292.38

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