209540-67-0

209540-67-0 structure
209540-67-0 structure
  • Name: FDGlcU
  • Chemical Name: FDGlcU
  • CAS Number: 209540-67-0
  • Molecular Formula: C39H28F5NO18
  • Molecular Weight: 893.63
  • Catalog: Research Areas Others
  • Create Date: 2022-10-17 06:17:34
  • Modify Date: 2025-11-25 17:47:43
  • FDGlcU can be used as a fluorescent probe for non-invasively image with a high level of fluorescent activity. FDGlcU is non-fluorescent when the fluorescein is conjugated with two mono-glucuronides (Ex/Em=480/514 nm)[1].

Name FDGlcU
Description FDGlcU can be used as a fluorescent probe for non-invasively image with a high level of fluorescent activity. FDGlcU is non-fluorescent when the fluorescein is conjugated with two mono-glucuronides (Ex/Em=480/514 nm)[1].
Related Catalog
In Vitro FDGlcU (0.5 μg/mL; 12 h) shows enzymatic activity and inhibits βG activity in live bacteria[1].
In Vivo FDGlcU (7.3 μM/kg) can be used for in vivo time-lapse imaging of bacterial βG activity[1]. FDGlcU can be used for real-time imaging in vivo[1]. Guidelines (Following is our recommended protocol. This protocol only provides a guideline, and should be modified according to your specific needs). Whole-body imaging for intestinal βG activity[1]: 1. On the day of imaging, gavage mice with 50 μL of DDW, FDGlcU (7.3 μM/kg), and fluorescein (7.3 μM/kg). 2. Anesthetize mice with isoflurane and whole-body optical images using an IVIS spectrum optical imaging system with a GFP filter set. 3. In biodistribution study, mice are sacrificed 3 hour after gavaged with FDGlcU or fluorescein (λex =480 nm, λem =514 nm).
References

[1]. Chen M, et al. Real-time imaging of intestinal bacterial β-glucuronidase activity by hydrolysis of a fluorescent probe. Sci Rep. 2017 Jun 9;7(1):3142.

Molecular Formula C39H28F5NO18
Molecular Weight 893.63
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