2786829-70-5
2786829-70-5 structure
- Name: BCP-T.A
- Chemical Name: BCP-T.A
- CAS Number: 2786829-70-5
- Molecular Formula: C23H19Cl2N3OS
- Molecular Weight: 456.39
- Catalog: Signaling Pathways Apoptosis Ferroptosis
- Create Date: 2022-10-19 13:29:37
- Modify Date: 2024-04-05 18:12:41
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BCP-T.A, a tunable heterocyclic electrophile, is a potent ferroptosis inducer by binding to GPX4[1].
| Name | BCP-T.A |
|---|
| Description | BCP-T.A, a tunable heterocyclic electrophile, is a potent ferroptosis inducer by binding to GPX4[1]. |
|---|---|
| Related Catalog | |
| Target |
GPX4[1] |
| In Vitro | BCP-T.A induces ferroptosis in various cell lines (NCI-H522, T-1080, MDA-MB-468, MDA-MB-231, HeLa, HCT-116, U2OS, WI-38, and MEFS) with IC50 values of 10 nM-367 nM[1]. BCP-T.A (0.5 μM, 3 h) binds to GPX4 and increases lipid peroxides, indicated by cellular thermal shift assay (CETSA)[1]. |
| References |
| Molecular Formula | C23H19Cl2N3OS |
|---|---|
| Molecular Weight | 456.39 |