233605-81-7
233605-81-7 structure
- Name: AV123
- Chemical Name: AV123
- CAS Number: 233605-81-7
- Molecular Formula: C11H14N4O2
- Molecular Weight: 234.25
- Catalog: Signaling Pathways Apoptosis RIP kinase
- Create Date: 2022-10-11 10:43:27
- Modify Date: 2024-01-14 19:58:52
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AV123 (compound 12) is a non-cytotoxic RIPK1 inhibitor (IC50=12.12 µM). AV123 blocks the TNF-α-induced necroptotic (EC50=1.7 μM) but not the apoptotic cell death. AV123 can be used in the study of necrotic chronic conditions such as ischemia-reperfusion injury of the brain, heart and kidney, inflammatory diseases, neurodegenerative diseases and infectious diseases[1].
| Name | AV123 |
|---|
| Description | AV123 (compound 12) is a non-cytotoxic RIPK1 inhibitor (IC50=12.12 µM). AV123 blocks the TNF-α-induced necroptotic (EC50=1.7 μM) but not the apoptotic cell death. AV123 can be used in the study of necrotic chronic conditions such as ischemia-reperfusion injury of the brain, heart and kidney, inflammatory diseases, neurodegenerative diseases and infectious diseases[1]. |
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| Related Catalog | |
| Target |
IC50: 0.48 µM (CDK9/ CyclinT), 0.80 µM (CLK1 of Mus musculus), 1.80 µM (DYRK1A of Rattus norvegicus), >10 µM (CDK2/CyclinA, CDK5/p25, HASPIN, Pim1, CK1 ε, JAK3, ABL1, RIPK3, AURKB)[1]. |
| In Vitro | AV123 (0.01-100 µM; 24 h) efficiently blocks necroptosis in a dose-dependent manner in FADD-deficient Jurkat cells[1]. AV123 (0.01-50 µM; 24 h) shows no toxicity to RPE-1 cells[1]. Cell Viability Assay[1] Cell Line: FADD-deficient Jurkat cells Concentration: 0.01-100 µM Incubation Time: 24 h Result: Significantly blocked the necroptotic cell-death induced by TNF-α with an EC50 value of 1.7 µM. Cell Cytotoxicity Assay[1] Cell Line: RPE-1 cells Concentration: 0.01-50 µM Incubation Time: 24 h Result: Exhibited no toxicity to RPE-1 cells. |
| References |
| Molecular Formula | C11H14N4O2 |
|---|---|
| Molecular Weight | 234.25 |