2204289-53-0

2204289-53-0 structure

Name: SHIN-2
Chemical Name: Pyrano[2,3-c]pyrazole-5-carbonitrile, 6-amino-1,4-dihydro-4-[3-(hydroxymethyl)-5-(5-hydroxy-1-pentyn-1-yl)phenyl]-3-methyl-4-(1-methylethyl)-
CAS Number: 2204289-53-0
Molecular Formula: C₂₃H₂₆N₄O₃
Molecular Weight: 406.48
Catalog: Research Areas Others
Create Date: 2022-09-12 16:14:26
Modify Date: 2025-08-26 00:16:13
(Rac)-SHIN2 is a serine hydroxymethyltransferase (SHMT) inhibitor having 1,4-dihydropyrano[2,3-c]pyrazole structure. (Rac)-SHIN2 involves in folate or one-carbon metabolism pathways, prevents viral infection. SHMT1 and SHMT2 are the cytosolic and/or mitochondrial isoforms of serine hydroxymethyltransferase, respectively[1].

Name	Pyrano[2,3-c]pyrazole-5-carbonitrile, 6-amino-1,4-dihydro-4-[3-(hydroxymethyl)-5-(5-hydroxy-1-pentyn-1-yl)phenyl]-3-methyl-4-(1-methylethyl)-
Synonyms	SHIN-2

Description	(Rac)-SHIN2 is a serine hydroxymethyltransferase (SHMT) inhibitor having 1,4-dihydropyrano[2,3-c]pyrazole structure. (Rac)-SHIN2 involves in folate or one-carbon metabolism pathways, prevents viral infection. SHMT1 and SHMT2 are the cytosolic and/or mitochondrial isoforms of serine hydroxymethyltransferase, respectively[1].
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others
Target	Serine hydroxymethyltransferase (SHMT)[1]
References	[1]. Mootha Vamsi, et al. Method of treating and preventing viral infection comprising inhibitors of folate or one-carbon metabolism pathways such as serine hydroxymethyltransferase inhibitors: World Intellectual Property Organization, WO2022120195[P]. 2022-06-09.

Molecular Formula	C₂₃H₂₆N₄O₃
Molecular Weight	406.48