2414240-89-2
2414240-89-2 structure
- Name: SMS2-IN-3
- Chemical Name: SMS2-IN-3
- CAS Number: 2414240-89-2
- Molecular Formula: C33H39F3N4O6
- Molecular Weight: 644.68
- Catalog: Research Areas Others
- Create Date: 2022-09-11 06:21:22
- Modify Date: 2025-08-26 10:01:05
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SMS2-IN-3 is a potent and selective SMS2inhibitor (IC50=2.2 nM), significantly reduces the hepatic SM (22:0) levels[1].
| Name | SMS2-IN-3 |
|---|
| Description | SMS2-IN-3 is a potent and selective SMS2inhibitor (IC50=2.2 nM), significantly reduces the hepatic SM (22:0) levels[1]. |
|---|---|
| Related Catalog | |
| Target |
IC50: 2.2nM (SMS2)[1] |
| In Vitro | SMS2-IN-3 (37) is an excellent sphingomyelin synthase 2 inhibitor (SMS2). SMS2-IN-3 (37) has inhibition (IC50= 2.2 nM) and good selectivity against SMS1[1]. Cell Viability Assay[1] Cell Line: FreeStyle293 cells Concentration: 100mg/kg Incubation Time: 60 min Result: Showed excellent SMS2 inhibition and good selectivity against SMS1 in biological evaluation. |
| In Vivo | SMS2-IN-3 (37) has excellent SMS2 activity and high selectivity against SMS1. SMS2-IN-3 also reduces the level of SM by subcutaneous treatment[1]. Animal Model: KK-Ay/Ta mice[1] Dosage: 100, 200 mg/kg Administration: SMS2-IN-3: s.c. (100, 200 mg/kg); p.o. (100, 200 mg/kg); once or twice per day for 7 days. Result: cmpd Cmax, (μg/mL) Tmax, (h) C24 h, (μg/mL) AUC0-24(μg•h/mL) MRT(h) 37(p.o.) 6.5 0.83 0.007 18 3.0 37(s.c.) 0.70 8.0 0.23 12 9.4 |
| References |
| Molecular Formula | C33H39F3N4O6 |
|---|---|
| Molecular Weight | 644.68 |