1198621-85-0

1198621-85-0 structure

Name: ODN D-SL03
Chemical Name: ODN D-SL03
CAS Number: 1198621-85-0
Molecular Formula:
Molecular Weight:
Catalog: Signaling Pathways Immunology/Inflammation IFNAR
Create Date: 2022-08-30 19:41:32
Modify Date: 2024-01-12 11:01:36
ODN D-SL03 is a C class CpG oligonucleotides, can induce stimulate PBMCs to produce high level of IFN-α. ODN D-SL03 can activate human B cells, NK cells and mononuclear cells and up-regulate expression of CD80, CD86 and HLA-DR on the surface of subsets in human PBMCs. ODN D-SL03 also can inhibit the growth of the tumor. ODN D-SL03 sequence: 5'-tcgcgaacgttcgccgcgttcgaacgcgg-3'[1].

Name	ODN D-SL03

Description	ODN D-SL03 is a C class CpG oligonucleotides, can induce stimulate PBMCs to produce high level of IFN-α. ODN D-SL03 can activate human B cells, NK cells and mononuclear cells and up-regulate expression of CD80, CD86 and HLA-DR on the surface of subsets in human PBMCs. ODN D-SL03 also can inhibit the growth of the tumor. ODN D-SL03 sequence: 5'-tcgcgaacgttcgccgcgttcgaacgcgg-3'[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Immunology/Inflammation >> IFNAR Research Areas >> Inflammation/Immunology
Target	IFN-α[1]
In Vitro	ODN D-SL03 (0-3 μg/mL; 36 h) significantly induces IFN-α production in PBMCs at 0.19 μg/mL[1]. ODN D-SL03 (3 μg/mL; 18 or 36 h) activates immune cells including B, NK, T and monocyte cells[1].
In Vivo	ODN D-SL03 (25 μg per mouse; Peritumoral injection) induces significant inhibition of tumor growth[1]. Animal Model: Female BALB/c mice (6-8 weeks; inoculated with 5×105 EMT6 cells)[1] Dosage: 25 μg per mouse Administration: Peritumoral injection, six times in one-day interval, for 0-100 days Result: Induced significant inhibition of tumor growth.
References	[1]. Yang L, et al. CpG oligodeoxynucleotides with double stem-loops show strong immunostimulatory activity. Int Immunopharmacol. 2013 Jan;15(1):89-96.

No Any Chemical & Physical Properties