2410794-89-5

2410794-89-5 structure

Name: GRK5-IN-4
Chemical Name: GRK5-IN-4
CAS Number: 2410794-89-5
Molecular Formula: C₂₆H₂₅N₇O₃
Molecular Weight: 483.52
Catalog: Research Areas Cardiovascular Disease
Create Date: 2022-09-18 16:27:59
Modify Date: 2024-04-08 05:14:18
GRK5-IN-4 (Compound 16d, CCG-265328) is a potent and and selective covalent GRK5 (G protein-coupled receptor kinase 5) inhibitor, with an IC50 of 1.1 μM. GRK5-IN-4 shows 90-fold selectivity over GRK2. GRK5-IN-4 can be used for heart failure research[1].

Name	GRK5-IN-4

Description	GRK5-IN-4 (Compound 16d, CCG-265328) is a potent and and selective covalent GRK5 (G protein-coupled receptor kinase 5) inhibitor, with an IC50 of 1.1 μM. GRK5-IN-4 shows 90-fold selectivity over GRK2. GRK5-IN-4 can be used for heart failure research[1].
Related Catalog	Research Areas >> Cardiovascular Disease
Target	IC50: 1.1 ± 0.4 μM (GRK5), 1.8 ± 2 μM (GRK6), >100 μM (GRK2)[1]
In Vitro	GRK5-IN-4 (Compound 16d) (0-4 h) displays a marked increase in apparent potency as a function of time[1].
References	[1]. Rowlands RA, et al. Structure-Based Design of Selective, Covalent G Protein-Coupled Receptor Kinase 5 Inhibitors. ACS Med Chem Lett. 2019 Nov 12;10(12):1628-1634.

Molecular Formula	C₂₆H₂₅N₇O₃
Molecular Weight	483.52