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2580941-14-4

2580941-14-4 structure

2580941-14-4 structure

Name: Estrogen receptor β antagonist 2
Chemical Name: Estrogen receptor β antagonist 2
CAS Number: 2580941-14-4
Molecular Formula: C₂₃H₂₆N₂O₆
Molecular Weight: 426.46
Catalog: Research Areas Cancer
Create Date: 2022-09-11 09:01:04
Modify Date: 2024-09-08 00:42:41
Estrogen receptor β antagonist 2 is a potent and selective estrogen receptor β (ERβ) antagonist with IC50s of 109.10, 0.63 µM for Erα and Erβ, respectively[1].

Name	Estrogen receptor β antagonist 2

Description	Estrogen receptor β antagonist 2 is a potent and selective estrogen receptor β (ERβ) antagonist with IC50s of 109.10, 0.63 µM for Erα and Erβ, respectively[1].
Related Catalog	Signaling Pathways >> Others >> Estrogen Receptor/ERR Research Areas >> Cancer
Target	ERα:109.10 μM (IC50) ERβ:0.63 μM (IC50)
In Vitro	Estrogen receptor β antagonist 2 (compound 42) (0-100 µM) shows antiproliferative activity with IC50 value of >100 µM in MCF-7cells[1]. .Estrogen receptor β antagonist 2 exhibits differences in interaction potential to H12 of ERβ via Asp303 (H3) H-bonding to Tyr488[1].
References	[1]. Carr M, et al. Optimisation of estrogen receptor subtype-selectivity of a 4-Aryl-4H-chromene scaffold previously identified by virtual screening. Bioorg Med Chem. 2020 Mar 1;28(5):115261.

Molecular Formula	C₂₃H₂₆N₂O₆
Molecular Weight	426.46