2562384-19-2

2562384-19-2 structure

Name: CYP3A4-IN-3
Chemical Name: CYP3A4-IN-3
CAS Number: 2562384-19-2
Molecular Formula: C₃₄H₃₉N₃O₃S
Molecular Weight: 569.76
Catalog: Signaling Pathways Metabolic Enzyme/Protease Cytochrome P450
Create Date: 2022-09-04 19:14:01
Modify Date: 2024-08-09 16:36:20
CYP3A4-IN-3 is a high-affinity specific inhibitor of cytochrome P450 3A4 (CYP3A4) with the IC50 value of 0.075 μM. CYP3A4-IN-3 is a ritonavir analogue, but with a simpler structure and twice the inhibitory effect of ritonavir. CYP3A4-IN-3 is used as an antiviral agent and immunosuppressant[1].

Name	CYP3A4-IN-3

Description	CYP3A4-IN-3 is a high-affinity specific inhibitor of cytochrome P450 3A4 (CYP3A4) with the IC50 value of 0.075 μM. CYP3A4-IN-3 is a ritonavir analogue, but with a simpler structure and twice the inhibitory effect of ritonavir. CYP3A4-IN-3 is used as an antiviral agent and immunosuppressant[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Metabolic Enzyme/Protease >> Cytochrome P450 Research Areas >> Inflammation/Immunology
Target	CYP3A4:0.075 μM (IC50)
References	[1]. Eric R Samuels, et al. An increase in side-group hydrophobicity largely improves the potency of ritonavir-like inhibitors of CYP3A4. Bioorg Med Chem. 2020 Mar 15;28(6):115349. doi: 10.1016/j.bmc.2020.115349. Epub 2020 Jan 31.

Molecular Formula	C₃₄H₃₉N₃O₃S
Molecular Weight	569.76