135025-12-6
135025-12-6 structure
- Name: CP-113818
- Chemical Name: CP-113818
- CAS Number: 135025-12-6
- Molecular Formula: C24H42N2OS3
- Molecular Weight: 470.80
- Catalog: Research Areas Neurological Disease
- Create Date: 2022-09-22 13:35:35
- Modify Date: 2024-04-06 13:45:33
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CP-113818 is a potent cholesterol acyltransferase (ACAT) inhibitor. CP-113818 can be used for the research of Alzheimer's disease[1].
| Name | CP-113818 |
|---|
| Description | CP-113818 is a potent cholesterol acyltransferase (ACAT) inhibitor. CP-113818 can be used for the research of Alzheimer's disease[1]. |
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| Related Catalog | |
| In Vitro | CP-113818 inhibits Aβ production in cell-based experiments[1]. |
| In Vivo | CP-113818 (0-7.1 mg/kg/day) markedly reduces amyloid pathology in a mouse model of Alzheimer's disease[1]. Animal Model: C57BL/6, hAPP (human amyloid precursor protein) transgenic mice[1] Dosage: 0, 0.2, 1.6, 3.2, 4.8, and 7.1 mg/kg/day Administration: Via implantable slow-release biopolymer pellets, 21 days for nontransgenic mice or 60 days for hAPP mice Result: Reduced total cholesterol levels by 29% in the serum, hepatic free cholesterol and cholesteryl-esters were also decreased in a dose-dependent manner by up to 37% and 93%, respectively in the nontransgenic mice. Effectively reduced cholesteryl-ester levels of hAPP mice in the absence of adrenal toxicity, reduced plaque numbers, and decreased amyloid load in a gender-independent manner in hAPP mice. Reduced levels of “insoluble” and soluble Aβ1-40 and Aβ1-42 in the brains of hAPP transgenic mice. Restored normal spatial learning and memory in female hAPP mice in a morris water maze test. Reduced processing of endogenous APP but not notch or N-cadherin, without directly inhibiting β- and γ-secretase activities or Aβ aggregation in nontransgenic littermates. |
| References |
| Molecular Formula | C24H42N2OS3 |
|---|---|
| Molecular Weight | 470.80 |