2750413-99-9

2750413-99-9 structure

2750413-99-9 structure

Name: CCG-273463
Chemical Name: CCG-273463
CAS Number: 2750413-99-9
Molecular Formula: C₂₆H₂₅BrN₄O₃
Molecular Weight: 521.41
Catalog: Research Areas Cancer
Create Date: 2022-08-31 22:20:42
Modify Date: 2023-02-03 14:07:59
CCG-273463 is a potent, selective and covalent GRK5 inhibitor with an IC50 value of 9 nM. CCG-273463 can be used in the research of heart failure, hypertrophic cardiomyopathy, and cancer[1].

Name	CCG-273463

Description	CCG-273463 is a potent, selective and covalent GRK5 inhibitor with an IC50 value of 9 nM. CCG-273463 can be used in the research of heart failure, hypertrophic cardiomyopathy, and cancer[1].
Related Catalog	Research Areas >> Cancer Research Areas >> Cardiovascular Disease
Target	IC50: 8.6 nM (GRK5), 12 μM (GRK2)[1].
In Vitro	CCG-273463 (0.02-1 μM) potently and highly inhibits GRK5 (IC50: 9 nM), with inhibitory rate of 93% (GRK5) and 97% (GRK6) at 1 μM[1].
References	[1]. Rachel A Rowlands, et al. Generation of Highly Selective, Potent, and Covalent G Protein-Coupled Receptor Kinase 5 Inhibitors. J Med Chem. 2021 Jan 14;64(1):566-585.

Molecular Formula	C₂₆H₂₅BrN₄O₃
Molecular Weight	521.41