848256-17-7
848256-17-7 structure
- Name: AIMP2-DX2-IN-1
- Chemical Name: AIMP2-DX2-IN-1
- CAS Number: 848256-17-7
- Molecular Formula: C23H21NO3
- Molecular Weight: 359.42
- Catalog: Research Areas Cancer
- Create Date: 2022-09-17 23:30:43
- Modify Date: 2024-01-10 16:04:14
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AIMP2-DX2-IN-1 (Compound 35) is a potent AIMP2-DX2 inhibitor with an IC50 of 0.1063 μM[1].
| Name | AIMP2-DX2-IN-1 |
|---|
| Description | AIMP2-DX2-IN-1 (Compound 35) is a potent AIMP2-DX2 inhibitor with an IC50 of 0.1063 μM[1]. |
|---|---|
| Related Catalog | |
| Target |
IC50: 0.1063 μM (AIMP2-DX2)[1] |
| In Vitro | AIMP2-DX2-IN-1 (Compound 35) (0-1 μM, 96 h) shows inhibitory activity against A549 and H460 cells without toxicity for normal cells[1]. AIMP2-DX2-IN-1 showes very poor metabolic stability and good plasma stability in both human and mouse, and CYP inhibition need to be improved[1]. Cell Viability Assay[1] Cell Line: A549, H460 and WI-26 Concentration: 0-1 μM Incubation Time: 96 h Result: Showed inhibitory activities with EC50s of 0.690 ± 0.648 μM and 0.150 ± 0.062 μM against A549 and H460 cells, respectively. And is not active for WI-26. |
| References |
| Molecular Formula | C23H21NO3 |
|---|---|
| Molecular Weight | 359.42 |