2407654-51-5

2407654-51-5 structure

Name: ZXH-1-161
Chemical Name: ZXH-1-161
CAS Number: 2407654-51-5
Molecular Formula: C₂₆H₂₄N₆O₃
Molecular Weight: 468.51
Catalog: Signaling Pathways PROTAC Ligand for E3 Ligase
Create Date: 2022-08-18 09:41:29
Modify Date: 2024-01-14 16:31:25
ZXH-1-161 is a potent cereblon (CRBN) modulator with an IC50 value of 39 nM in MM1.S wild type cells. ZXH-1-161 has selective degradation activity towards GSPT1. ZXH-1-161 can be used for researching multiple myeloma[1].

Name	ZXH-1-161

Description	ZXH-1-161 is a potent cereblon (CRBN) modulator with an IC50 value of 39 nM in MM1.S wild type cells. ZXH-1-161 has selective degradation activity towards GSPT1. ZXH-1-161 can be used for researching multiple myeloma[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> Ligand for E3 Ligase
Target	IC50: 39 μM in MM1.S wild type cells[1]
References	[1]. Powell CE, et al. Selective Degradation of GSPT1 by Cereblon Modulators Identified via a Focused Combinatorial Library. ACS Chem Biol. 2020 Oct 16;15(10):2722-2730.

Molecular Formula	C₂₆H₂₄N₆O₃
Molecular Weight	468.51