1422527-84-1
1422527-84-1 structure
- Name: Tafasitamab
- Chemical Name: Tafasitamab
- CAS Number: 1422527-84-1
- Molecular Formula:
- Molecular Weight:
- Catalog: Signaling Pathways Apoptosis Apoptosis
- Create Date: 2022-08-16 00:08:40
- Modify Date: 2024-01-04 13:18:18
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Tafasitamab is an Fc-modified, humanized monoclonal antibody that binds to the human B-cell surface antigenCD19[1][2].
| Name | Tafasitamab |
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| Description | Tafasitamab is an Fc-modified, humanized monoclonal antibody that binds to the human B-cell surface antigenCD19[1][2]. |
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| Related Catalog | |
| In Vitro | Tafasitamab induces cytotoxicity against Mino and Jeko (MCL) cell lines in an E/T ratio-dependent manner XmAb5574 increases ADCP and antiproliferative activity. Tafasitamab (XmAb5574) enhances antiproliferative apoptotic activity due to caspase-induced apoptosis[1][2]. Cell Cytotoxicity Assay[1] Cell Line: NHL cell lines and primary CLL and MCL cells by γδ T cells Concentration: Incubation Time: 2 h Result: Induced killing of NHL cell lines and primary CLL and MCL cells by γδ T cells. Cell Proliferation Assay[2] Cell Line: SU-DHL-6 cells Concentration: Incubation Time: 72 h Result: Showed potent antiproliferative effects on tumor cell. Apoptosis Analysis[2] Cell Line: SU-DHL-6 cells Concentration: 0-4 ng/mL Incubation Time: 48 h Result: Showed potent antiproliferative effects due to caspase-induced apoptosis |
| In Vivo | Tafasitamab (SC, once on Day 1, 2.5 μg/kg) inhibits lymphoma growth in disseminated BL mouse xenograft tumor models[1]. Animal Model: Disseminated Raji model[1]. Dosage: 2.5 μg/kg Administration: Tafasitamab (SC, once on Day 1, 2.5 μg/kg) Result: Showed antitumor activity in disseminated Raji model. Animal Model: Disseminated Ramos model[1]. Dosage: 10 mg/kg Administration: Tafasitamab (IV, on Days 3, 6, 10, 13, 17, and 20 at a dose of 10 mg/kg) Result: Showed antitumor activity in disseminated Ramos model. |
| References |
| No Any Chemical & Physical Properties |