2414607-10-4

2414607-10-4 structure

Name: SKLB0565
Chemical Name: SKLB0565
CAS Number: 2414607-10-4
Molecular Formula: C₂₀H₂₅ClN₆O
Molecular Weight: 400.91
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2022-08-16 13:39:24
Modify Date: 2024-01-02 18:08:52
SKLB0565 is a potent tubulin inhibitor. SKLB0565 shows significant anti-proliferative activity against CRC (colorectal carcinoma) cell lines, with IC50 values ranging from 0.012 μM to 0.081 μM. SKLB0565 causes G2/M phase arrest and mitochondria-mediated intrinsic apoptosis. SKLB0565 inhibits cell migration and disrupted the tube formation of HUVECs[1].

Name	SKLB0565

Description	SKLB0565 is a potent tubulin inhibitor. SKLB0565 shows significant anti-proliferative activity against CRC (colorectal carcinoma) cell lines, with IC50 values ranging from 0.012 μM to 0.081 μM. SKLB0565 causes G2/M phase arrest and mitochondria-mediated intrinsic apoptosis. SKLB0565 inhibits cell migration and disrupted the tube formation of HUVECs[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Microtubule/Tubulin Signaling Pathways >> Cytoskeleton >> Microtubule/Tubulin
References	[1]. Hu X, et al. Design, synthesis and biological evaluation of a novel tubulin inhibitor SKLB0565 targeting the colchicine binding site. Bioorg Chem. 2020 Apr;97:103695.

Molecular Formula	C₂₀H₂₅ClN₆O
Molecular Weight	400.91