1801547-15-8
1801547-15-8 structure
- Name: PROTAC_ERRα
- Chemical Name: PROTAC_ERRα
- CAS Number: 1801547-15-8
- Molecular Formula: C46H47F3N6O9S2
- Molecular Weight: 949.03
- Catalog: Signaling Pathways Epigenetics Epigenetic Reader Domain
- Create Date: 2022-08-11 17:42:13
- Modify Date: 2024-01-15 23:38:14
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PROTAC_ERRα is a potent and selective ERRα degrader. PROTAC_ERRα induces proteasomal degradation and has capable of specifically degrading ERRα protein by >80%[1].
| Name | PROTAC_ERRα |
|---|
| Description | PROTAC_ERRα is a potent and selective ERRα degrader. PROTAC_ERRα induces proteasomal degradation and has capable of specifically degrading ERRα protein by >80%[1]. |
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| Related Catalog | |
| In Vitro | PROTAC_ERRα (0-1000 nM; 8 hours; MCF7 cells) down-regulates ERRα protein levels in a dose-dependent fashion[1]. PROTAC_ERRα (100-500 nM; 4-24 hours; MCF7 cells) possesses good selectivity for ERRα target and decreases protein levels of ERRα downstream target genes[1]. Western Blot Analysis[1] Cell Line: MCF7 cells Concentration: 0, 10, 30, 100, 300 and 1000 nM Incubation Time: 8 hours Result: Decreased in ERRα level in a dose-dependent fashion and the maximal level of degradation (D50) is 86%. |
| In Vivo | PROTAC_ERRα (100 mg/kg; i.p.; every eight hours) degrades ERRα level in vivo[1]. Animal Model: Female CD-1 mice[1] Dosage: 100 mg/kg Administration: Intraperitoneal injection ; every eight hours. Result: Reduced ERRα levels in mouse heart and kidney and MDA-MB-231 tumors by approximately 44%, 44% and 39%, respectively. |
| References |
| Molecular Formula | C46H47F3N6O9S2 |
|---|---|
| Molecular Weight | 949.03 |